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1

The mutational landscape of 18 investigated genes clearly separates four subtypes of myelodysplastic/myeloproliferative neoplasms

Meggendorfer, Manja, Jeromin, Sabine, Haferlach, Claudia, Kern, Wolfgang, Haferlach, Torsten

Journal:

Year:

2018

Language:

english

File:

PDF, 691 KB

english, 2018

2

Dynamics of clonal evolution in myelodysplastic syndromes

Makishima, Hideki, Yoshizato, Tetsuichi, Yoshida, Kenichi, Sekeres, Mikkael A, Radivoyevitch, Tomas, Suzuki, Hiromichi, Przychodzen, Bartlomiej, Nagata, Yasunobu, Meggendorfer, Manja, Sanada, Masashi,

Journal:

Nature Genetics

Year:

2016

Language:

english

File:

PDF, 1.41 MB

english, 2016

3

Clonal interference of signaling mutations holds prognostic relevance in core binding factor acute myeloid leukemia

Itzykson, Raphael, Duployez, Nicolas, Fasan, Annette, Decool, Gauthier, Marceau-Renaut, Alice, Meggendorfer, Manja, Jourdan, Eric, Petit, Arnaud, Lapillonne, Hélène, Micol, Jean-Baptiste, Cornillet-Le

Journal:

Year:

2018

Language:

english

File:

PDF, 1.80 MB

english, 2018

4

Cytogenetic and molecular genetic characterization of KMT2A-PTD positive acute myeloid leukemia in comparison to KMT2A-Rearranged acute myeloid leukemia

Vetro, Calogero, Haferlach, Torsten, Meggendorfer, Manja, Stengel, Anna, Jeromin, Sabine, Kern, Wolfgang, Haferlach, Claudia

Journal:

Cancer Genetics

Year:

2020

Language:

english

File:

PDF, 1.69 MB

english, 2020

5

Functional nuclear topography of transcriptionally inducible extra-chromosomal transgene clusters

Manja Meggendorfer, Claudia Weierich, Horst Wolff, Ruth Brack-Werner, Thomas Cremer

Journal:

Chromosome Research

Year:

2010

Language:

english

File:

PDF, 654 KB

english, 2010

6

Stably integrated and expressed retroviral sequences can influence nuclear location and chromatin condensation of the integration locus

Nagel, Jens, Groß, Birgit, Meggendorfer, Manja, Preiss, Carolin, Grez, Manuel, Brack-Werner, Ruth, Dietzel, Steffen

Journal:

Year:

2012

Language:

english

File:

PDF, 969 KB

english, 2012

7

Investigation of 305 patients with myelodysplastic syndromes and 20q deletion for associated cytogenetic and molecular genetic lesions and their prognostic impact

Bacher, Ulrike, Haferlach, Torsten, Schnittger, Susanne, Zenger, Melanie, Meggendorfer, Manja, Jeromin, Sabine, Roller, Andreas, Grossmann, Vera, Krauth, Maria-Theresa, Alpermann, Tamara, Kern, Wolfga

Journal:

British Journal of Haematology

Year:

2014

Language:

english

File:

PDF, 378 KB

english, 2014

8

AML with gain of chromosome 8 as the sole chromosomal abnormality (+8sole) is associated with a specific molecular mutation pattern including ASXL1 mutations in 46.8% of the patients

Alpermann, Tamara, Haferlach, Claudia, Eder, Christiane, Nadarajah, Niroshan, Meggendorfer, Manja, Kern, Wolfgang, Haferlach, Torsten, Schnittger, Susanne

Journal:

Leukemia Research

Year:

2015

Language:

english

File:

PDF, 850 KB

english, 2015

9

The 5q deletion size in myeloid malignancies is correlated to additional chromosomal aberrations and to TP53 mutations

Stengel, Anna, Kern, Wolfgang, Haferlach, Torsten, Meggendorfer, Manja, Haferlach, Claudia

Journal:

Genes, Chromosomes and Cancer

Year:

2016

Language:

english

File:

PDF, 2.33 MB

english, 2016

10

A new model for post-integration latency in macroglial cells to study HIV-1 reservoirs of the brain

Schneider, Martha, Tigges, Bianca, Meggendorfer, Manja, Helfer, Markus, Ziegenhain, Christoph, Brack-Werner, Ruth

Journal:

Year:

2015

Language:

english

File:

PDF, 658 KB

english, 2015

11

Application of an NGS-based 28-gene panel in myeloproliferative neoplasms reveals distinct mutation patterns in essential thrombocythaemia, primary myelofibrosis and polycythaemia vera

Delic, Sabit, Rose, Dominic, Kern, Wolfgang, Nadarajah, Niroshan, Haferlach, Claudia, Haferlach, Torsten, Meggendorfer, Manja

Journal:

British Journal of Haematology

Year:

2016

Language:

english

File:

PDF, 449 KB

english, 2016

12

Disease-modifying activity of ruxolitinib in a patient with JAK2 -negative CMML-2

Francke, Silvan, Mies, Anna, Meggendorfer, Manja, Oelschlaegel, Uta, Balaian, Ekaterina, Gloaguen, Silke, Haferlach, Torsten, Ehninger, Gerhard, Bornhäuser, Martin, Platzbecker, Uwe

Journal:

Leukemia and Lymphoma

Year:

2016

Language:

english

File:

PDF, 541 KB

english, 2016

13

Genomic Landscape of Acute Erythroid Leukemia

Iacobucci, Ilaria, Wen, Ji, Meggendorfer, Manja, Carmichael, Catherine, Choi, John, Li, Yongjin, Masih, Katherine, Payne-Turner, Debbie, Tomizawa, Daisuke, Kiyokawa, Nobutaka, Janke, Laura, Alexander,

Journal:

Clinical Lymphoma Myeloma and Leukemia

Year:

2016

Language:

english

File:

PDF, 458 KB

english, 2016

14

The clinical and molecular diversity of mast cell leukemia with or without associated hematologic neoplasm

Jawhar, Mohamad, Schwaab, Juliana, Meggendorfer, Manja, Naumann, Nicole, Horny, Hans-Peter, Sotlar, Karl, Haferlach, Torsten, Schmitt, Karla, Fabarius, Alice, Valent, Peter, Hofmann, Wolf-Karsten, Cro

Journal:

Year:

2017

Language:

english

File:

PDF, 1.95 MB

english, 2017

15

Molecular analysis of myelodysplastic syndrome with isolated del(5q) reveals a specific spectrum of molecular mutations with prognostic impact: a study on 123 patients and 27 genes

Meggendorfer, Manja, Haferlach, Claudia, Kern, Wolfgang, Haferlach, Torsten

Journal:

Year:

2017

Language:

english

File:

PDF, 1.86 MB

english, 2017

16

IDH1R132, IDH2R140 and IDH2R172 in AML: different genetic landscapes correlate with outcome and may influence targeted treatment strategies

Meggendorfer, Manja, Cappelli, Luca Vincenzo, Walter, Wencke, Haferlach, Claudia, Kern, Wolfgang, Falini, Brunangelo, Haferlach, Torsten

Journal:

Year:

2018

Language:

english

File:

PDF, 2.02 MB

english, 2018

17

Detection of recurrent and of novel fusion transcripts in myeloid malignancies by targeted RNA sequencing

Stengel, Anna, Nadarajah, Niroshan, Haferlach, Torsten, Dicker, Frank, Kern, Wolfgang, Meggendorfer, Manja, Haferlach, Claudia

Journal:

Year:

2018

Language:

english

File:

PDF, 426 KB

english, 2018

18

Minimal residual disease (MRD) monitoring and mutational landscape in AML with RUNX1-RUNX1T1: a study on 134 patients

Höllein, Alexander, Jeromin, Sabine, Meggendorfer, Manja, Fasan, Annette, Nadrarajah, Niroshan, Kern, Wolfgang, Haferlach, Claudia, Haferlach, Torsten

Journal:

Year:

2018

Language:

english

File:

PDF, 1.22 MB

english, 2018

19

Consequences of mutant TET2 on clonality and subclonal hierarchy

Hirsch, Cassandra M., Nazha, Aziz, Kneen, Kassy, Abazeed, Mohamed E., Meggendorfer, Manja, Przychodzen, Bartlomiej P., Nadarajah, Niroshan, Adema, Vera, Nagata, Yasunobu, Goyal, Abhinav, Awada, Hassan

Journal:

Year:

2018

Language:

english

File:

PDF, 2.47 MB

english, 2018

20

Identification of prognostic parameters in CLL with no abnormalities detected by chromosome banding and FISH analyses

Vetro, Calogero, Haferlach, Torsten, Jeromin, Sabine, Stengel, Anna, Zenger, Melanie, Nadarajah, Niroshan, Baer, Constance, Weissmann, Sandra, Kern, Wolfgang, Meggendorfer, Manja, Haferlach, Claudia

Journal:

British Journal of Haematology

Year:

2018

Language:

english

File:

PDF, 378 KB

english, 2018

21

Detection and characterization of homozygosity of mutated CALR by copy neutral loss of heterozygosity in myeloproliferative neoplasms among cases with high CALR mutation loads or with progressive disease

Stengel, Anna, Jeromin, Sabine, Haferlach, Torsten, Meggendorfer, Manja, Kern, Wolfgang, Haferlach, Claudia

Journal:

Year:

2018

Language:

english

File:

PDF, 265 KB

english, 2018

22

Detailed molecular analysis and evaluation of prognosis in cases with high grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements

Stengel, Anna, Kern, Wolfgang, Meggendorfer, Manja, Haferlach, Torsten, Haferlach, Claudia

Journal:

British Journal of Haematology

Year:

2018

Language:

english

File:

PDF, 128 KB

english, 2018

23

Efficacy of azacitidine is independent of molecular and clinical characteristics - an analysis of 128 patients with myelodysplastic syndromes or acute myeloid leukemia and a review of the literature

Kuendgen, Andrea, Müller-Thomas, Catharina, Lauseker, Michael, Haferlach, Torsten, Urbaniak, Petra, Schroeder, Thomas, Brings, Carolin, Wulfert, Michael, Meggendorfer, Manja, Hildebrandt, Barbara, Bet

Journal:

Year:

2018

Language:

english

File:

PDF, 2.25 MB

english, 2018

24

More than a fusion gene: the RUNX1 - RUNX1T1 AML

Haferlach, Torsten, Meggendorfer, Manja

Journal:

Year:

2019

File:

PDF, 722 KB

2019

25

More than a fusion gene: the RUNX1 - RUNX1T1 AML

Haferlach, Torsten, Meggendorfer, Manja

Journal:

Year:

2019

Language:

english

File:

PDF, 722 KB

english, 2019

26

Genomic subtyping and therapeutic targeting of acute erythroleukemia

Iacobucci, Ilaria, Wen, Ji, Meggendorfer, Manja, Choi, John K., Shi, Lei, Pounds, Stanley B., Carmichael, Catherine L., Masih, Katherine E., Morris, Sarah M., Lindsley, R. Coleman, Janke, Laura J., Al

Journal:

Nature Genetics

Year:

2019

Language:

english

File:

PDF, 2.43 MB

english, 2019

27

Impact of 9q deletions on the classification of patients with acute myeloid leukemia

Balk, Bettina, Haferlach, Torsten, Meggendorfer, Manja, Kern, Wolfgang, Haferlach, Claudia, Stengel, Anna

Journal:

Journal of Cancer Research and Clinical Oncology

Year:

2019

Language:

english

File:

PDF, 882 KB

english, 2019

28

Myeloid malignancies with isolated 7q deletion can be further characterized by their accompanying molecular mutations

Hartmann, Luise, Haferlach, Claudia, Meggendorfer, Manja, Kern, Wolfgang, Haferlach, Torsten, Stengel, Anna

Journal:

Genes, Chromosomes and Cancer

Year:

2019

Language:

english

File:

PDF, 1016 KB

english, 2019

29

Myeloid malignancies with isolated 7q deletion can be further characterized by their accompanying molecular mutations

Hartmann, Luise, Haferlach, Claudia, Meggendorfer, Manja, Kern, Wolfgang, Haferlach, Torsten, Stengel, Anna

Journal:

Genes, Chromosomes and Cancer

Year:

2019

File:

PDF, 1016 KB

2019

30

Somatic and pathogenic - Is the classification strategy applicable in times of large scale sequencing?

Baer, Constance, Walter, Wencke, Hutter, Stephan, Twardziok, Sven, Meggendorfer, Manja, Kern, Wolfgang, Haferlach, Torsten, Haferlach, Claudia

Journal:

Year:

2019

Language:

english

File:

PDF, 1.14 MB

english, 2019

31

Molecular characterization of acute myeloid leukemia patients who relapse more than 3 years after diagnosis: an exome sequencing study of 31 patients

Hartmann, Luise, Haferlach, Claudia, Meggendorfer, Manja, Nadarajah, Niroshan, Kern, Wolfgang, Haferlach, Torsten, Stengel, Anna

Journal:

Year:

2019

Language:

english

File:

PDF, 2.31 MB

english, 2019

32

Dark-matter matters: Discriminating subtle blood cancers using the darkest DNA

Parida, Laxmi, Haferlach, Claudia, Rhrissorrakrai, Kahn, Utro, Filippo, Levovitz, Chaya, Kern, Wolfgang, Nadarajah, Niroshan, Twardziok, Sven, Hutter, Stephan, Meggendorfer, Manja, Walter, Wencke, Bae

Journal:

PLoS Computational Biology

Year:

2019

Language:

english

File:

PDF, 1.95 MB

english, 2019

33

MARS: Mutation-Adjusted Risk Score for Advanced Systemic Mastocytosis

Jawhar, Mohamad, Schwaab, Juliana, Álvarez-Twose, Iván, Shoumariyeh, Khalid, Naumann, Nicole, Lübke, Johannes, Perkins, Cecelia, Muñoz-González, Javier I., Meggendorfer, Manja, Kennedy, Vanessa, Metzg

Journal:

Journal of Clinical Oncology

Year:

2019

Language:

english

File:

PDF, 1.00 MB

english, 2019

34

MARS: Mutation-Adjusted Risk Score for Advanced Systemic Mastocytosis

Jawhar, Mohamad, Schwaab, Juliana, Álvarez-Twose, Iván, Shoumariyeh, Khalid, Naumann, Nicole, Lübke, Johannes, Perkins, Cecelia, Muñoz-González, Javier I., Meggendorfer, Manja, Kennedy, Vanessa, Metzg

Journal:

Journal of Clinical Oncology

Year:

2019

File:

PDF, 1.00 MB

2019

35

Distinct and convergent consequences of splice factor mutations in myelodysplastic syndromes

Madan, Vikas, Li, Jia, Zhou, Siqin, Teoh, Weoi Woon, Han, Lin, Meggendorfer, Manja, Malcovati, Luca, Cazzola, Mario, Ogawa, Seishi, Haferlach, Torsten, Yang, Henry, Koeffler, H. Phillip

Journal:

American Journal of Hematology

Year:

2019

Language:

english

File:

PDF, 1.91 MB

english, 2019

36

Molecular characterization of a second myeloid neoplasm developing after treatment for acute myeloid leukemia

Hartmann, Luise, Nadarajah, Niroshan, Meggendorfer, Manja, Höllein, Alexander, Vetro, Calogero, Kern, Wolfgang, Haferlach, Torsten, Haferlach, Claudia, Stengel, Anna

Journal:

Year:

2019

Language:

english

File:

PDF, 613 KB

english, 2019

37

Molecular characterization of a second myeloid neoplasm developing after treatment for acute myeloid leukemia

Hartmann, Luise, Nadarajah, Niroshan, Meggendorfer, Manja, Höllein, Alexander, Vetro, Calogero, Kern, Wolfgang, Haferlach, Torsten, Haferlach, Claudia, Stengel, Anna

Journal:

Year:

2019

File:

PDF, 613 KB

2019

38

Molecular characterization of AML with RUNX1-RUNX1T1 at diagnosis and relapse reveals net loss of co-mutations

Höllein, Alexander, Nadarajah, Niroshan, Meggendorfer, Manja, Jeromin, Sabine, Kern, Wolfgang, Haferlach, Claudia, Haferlach, Torsten

Journal:

Year:

2019

File:

PDF, 4.09 MB

2019

39

The Combination of WGS and RNA-Seq is Superior to Conventional Diagnostic Tests in Multiple Myeloma: Ready for Prime Time?

Höllein, Alexander, Twardziok, Sven O., Walter, Wencke, Hutter, Stephan, Baer, Constance, Hernandez-Sanchez, Jesus Maria, Meggendorfer, Manja, Haferlach, Torsten, Kern, Wolfgang, Haferlach, Claudia

Journal:

Cancer Genetics

Year:

2020

File:

PDF, 1.38 MB

2020

40

Prognosis of MECOM ( EVI1 )-rearranged MDS and AML patients rather depends on accompanying molecular mutations than on blast count

Summerer, Isolde, Haferlach, Claudia, Meggendorfer, Manja, Kern, Wolfgang, Haferlach, Torsten, Stengel, Anna

Journal:

Leukemia and Lymphoma

Year:

2020

Language:

english

File:

PDF, 1022 KB

english, 2020

41

NPM1 mutated AML can relapse with wild-type NPM1: persistent clonal hematopoiesis can drive relapse

HÃ¶llein, Alexander, Meggendorfer, Manja, Dicker, Frank, Jeromin, Sabine, Nadarajah, Niroshan, Kern, Wolfgang, Haferlach, Claudia, Haferlach, Torsten

Journal:

Year:

2018

File:

PDF, 1.17 MB

2018

42

WGS and WTS in leukaemia: A tool for diagnostics?

Meggendorfer, Manja, Walter, Wencke, Haferlach, Torsten

Journal:

Best Practice & Research Clinical Haematology

Year:

2020

File:

PDF, 1.52 MB

2020

43

Male predominance in AML is associated with specific preleukemic mutations

De-Morgan, Aviv, Meggendorfer, Manja, Haferlach, Claudia, Shlush, Liran

Journal:

Year:

2020

File:

PDF, 1.35 MB

2020

44

Molecular landscape and clonal architecture of adult myelodysplastic/myeloproliferative neoplasms

Palomo, Laura, Meggendorfer, Manja, Hutter, Stephan, Twardziok, Sven, Adema, Vera, Fuhrmann, Irene, Fuster-Tormo, Francisco, Xicoy, Blanca, Zamora, Lurdes, Acha, Pamela, Kerr, Cassandra M, Kern, Wolfg

Journal:

Year:

2020

File:

PDF, 1.52 MB

2020

45

Complex landscape of alternative splicing in myeloid neoplasms

Hershberger, Courtney E., Moyer, Devlin C., Adema, Vera, Kerr, Cassandra M., Walter, Wencke, Hutter, Stephan, Meggendorfer, Manja, Baer, Constance, Kern, Wolfgang, Nadarajah, Niroshan, Twardziok, Sven

Journal:

Year:

2020

File:

PDF, 4.75 MB

2020

46

Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo

Rummelt, Christoph, Gorantla, Sivahari P., Meggendorfer, Manja, Charlet, Anne, Endres, Cornelia, DÃ¶hner, Konstanze, Heidel, Florian H., Fischer, Thomas, Haferlach, Torsten, Duyster, Justus, von Bubno

Journal:

Year:

2020

File:

PDF, 1.58 MB

2020

47

Whole transcriptome sequencing detects a large number of novel fusion transcripts in patients with AML and MDS

Stengel, Anna, Shahswar, Rabia, Haferlach, Torsten, Walter, Wencke, Hutter, Stephan, Meggendorfer, Manja, Kern, Wolfgang, Haferlach, Claudia

Journal:

Year:

2020

File:

PDF, 1.67 MB

2020

48

Next-generation diagnostics for precision oncology: preanalytical considerations, technical challenges, and available technologies

Walter, Wencke, Pfarr, Nicole, Meggendorfer, Manja, Jost, Philipp, Haferlach, Torsten, Weichert, Wilko

Journal:

Seminars in Cancer Biology

Year:

2020

File:

PDF, 3.70 MB

2020